Changes

<div style='"text-align: left;'">September 8-12, 2025<br />

<div style='"text-align: left;'">The eighth Complex Trait Analysis of Next Generation Sequence Data Course will be held at the [httpsTOPICS://www.mdc-berlin.de/ MDC] in Berlin Sequence alignment, calling variants from September 8 to 12NGS data, 2025. The course aims to teach the theory VCF format, bioinformatic annotation of variants and application regions, quality control of methods for analyzing next-generation sequence (NGS) data , association testing framework for complex human quantitative and qualitative traits. In addition to lectures[fixed effects, computer software will be used to analyze datarandom effects, linear mixed models (LMM) and problem-solving exercises will be performed to teach the trainees the latest method.generalized lMM (GLMM)], estimation of heritability, rare variant association methods, polygenic risk scores, pleiotropy, estimating power and sample size, and imputation of variants and their analysis</div>SOFTWARE: ANNOVAR, BCFtools, GCTA, Genetic Power Calculator, FASTLMM, LDSC regression, LDPHRED2, R, REGENIE

<div style='text-alignINSTRUCTORS: left;'>TOPICS: Sequence alignment, calling variants from NGS data, the VCF format, bioinformatic annotation of variants and regions, quality control of NGS data, association testing framework for quantitative and qualitative traits [fixed effects, random effects, linear mixed models Suzanne Leal (LMMColumbia University) and generalized lMM Michael Nothnagel (GLMMUniversity of Cologne)], estimation of heritability, rare variant association methods, polygenic risk scores, pleiotropy, estimating power and sample size, and imputation of variants and their analysis</div>.

<div styleFor additional information on the Complex Trait Analysis of NGS Data Course please contact [mailto:suzannemleal@gmail.com?subject='text-alignComplex%20Trait%20Analysis%20Course%20Berlin%202023 Suzanne Leal]: left;'>SOFTWAREEmail: ANNOVAR, BCFtools, GCTA, Genetic Power Calculator, FASTLMM, LDSC regression, LDPHRED2, R, REGENIE</div>[mailto:suzannemleal@gmail.com?subject=Complex%20Trait%20Analysis%20Course%20Berlin%202023 suzannemleal@gmail.com]

 <div style='text-align: left;'>INSTRUCTORS: Suzanne Leal (Columbia University) and Michael Nothnagel (University of Cologne).</div>  <div style='text-align: left;'>The cost of the 5-day course is &euro;975 for researchers from an academic institution, and &euro;1,950 for individuals from private (for-profit) companies. This fee covers tuition, A Monday evening welcome dinner, and course-related expenses (handouts, etc.) but not room, board, or additional meals. Housing is available for course participants at nearby hotels.</div>  <div style='text-align: left;'>For additional information on the Complex Trait Analysis of NGS Data Course please contact [mailto:suzannemleal@gmail.com?subject=Complex%20Trait%20Analysis%20Course%20Berlin%202023 Suzanne Leal]:Email: [mailto:suzannemleal@gmail.com?subject=Complex%20Trait%20Analysis%20Course%20Berlin%202023 suzannemleal@gmail.com]</div>  <div style='text-align: left;'>APPLICATION DEADLINE: June 15, 2025</div>    <div style='"text-align: left;'">[https://github.com/statgenetics/statgen-courses/blob/master/schedules/schedule_berlin_complex_ngs_2025.pdf Click here for the course schedule]</div> <div style='"text-align: left;'">[https://github.com/statgenetics/statgen-courses/raw/refs/heads/master/applications/Berlin_NGS_Complex_Trait_Application_2025.docx Click here for the application form]</div> <div style='"text-align: left;'">[https://github.com/statgenetics/statgen-courses/blob/master/flyer/Berlin_NGS_complex_traits_course_flyer_2025.pdf Click here for the course flyer (please post and distribute it)]</div>