Changes

November 2322-2726, 20202021<br />

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The sixth annual Berlin Complex Trait Analysis of Next Generation Sequence Data Course will be held at the [https://www.mdc-berlin.de/ MDC] in Berlin from November 2322-2726, 20202021. The goal of the course is to teach both the theory and application of methods to analyze next-generation sequence (NGS) data for human complex traits. Attendees will learn how to design studies, call variants from NGS data, analysis of population-, trio- and family-based sequence data , and evaluation of variant functionality. Analyses will include performing complex trait rare variant association analysis for population and trio family datavia linear mixed models. Exercises will be carried out using a variety of computer programs that include ANNOVAR, BOLT-LMM, FAST-GWA, IGV, R, REGENIE, PSEQ, & Variant Association Tools (VAT). TOPICS will include sequence alignment, calling variants from NGS data, quality control of NGS data, association testing framework for quantitative and qualitative traits (fixed effects, random effects, and generalized linear mixed models and linear mixed models), rare variant association methods, polygenic risk scores, estimating power and sample size for rare variant association studies, imputation of rare variants and their analysis, and evaluating variant conservation and functionality.

TOPICS will be include: sequence alignment, calling variants The cost of the 5-day course is 975 EUR for researchers from NGS dataan academic institution, quality control of NGS dataand 1, association testing framework 950 EUR for quantitative and qualitative traits individuals from private (fixed effectsfor profit) companies. This fee covers tuition, random effects Monday evening wine and generalized linear mixed models cheese party, and linear mixed modelscourse-related expenses (handouts, etc.)but not room, rare variant association methodsboard, polygenic risk scores, estimating power and sample size or meals. Inexpensive housing is available for rare variant association studies, imputation of rare variants and their analysis, and evaluating variant conservation course participants at the MDC and functionalitynearby hotels.

The cost of instructors for the 5-day course is 975 EUR for researchers from an academic institution, and 1,950 EUR for individuals from private are Suzanne Leal (for profitColumbia University) companies. This fee covers tuition, Monday evening wine and cheese party and course related expenses Michael Nothnagel (handouts, etc.University of Cologne) but not room, board or meals. Inexpensive housing is available for course participants at the MDC and nearby hotels.

The organizers and instructors for Vaccination is mandatory to attend the course are Suzanne Leal (Columbia University) and Michael Nothnagel (University of Cologne).

[http://statgen.us/files/20202021/11/schedule_berlin_complex_ngs_2020schedule_berlin_complex_ngs_2021.pdf Click here for course schedule]<br />[http://statgen.us/files/20202021/11/Berlin_NGS_Complex_Trait_Application_2020Berlin_NGS_Complex_Trait_Application_2021.html Click here for the application form]<br />[http://statgen.us/files/20202021/11/Berlin_NGS_complex_traits_course_flyer_2020Berlin_NGS_complex_traits_course_flyer_2021.pdf Click here for course flyer] (please post and distribute)<br />