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===September 5June 26-930, 20162017<br />Max Delbrück Center (MDC) for Molecular Medicine<br />Berlin, Germany===The seventh Annual eigth Annual Berlin Genetic Association Course will be held at the [http://www.mdc-berlin.de/ MDC] in Berlin from September 5-9, 2016. The goal of the course is to teach the course participants both theory and application of methods for population based association analysis, with a concentration on the analysis of exome and whole genome sequence and genotype data.

Emphasis in this course is on strategies for genetic mapping of complex human traits. It will include theory as well as practical exercises. The exercises will be carried out using a variety of computer programs (PLINK, GenABEL, MACH, UNPHASED, EIGENSTRAT, Variant Association Tools (VAT), SEQPower and R, etc.) and with pencil and paper. The emphasis of this course is analysis of population based whole genome and exome data including genotype and sequence data.  TOPICS include: Association analysis of qualitative and quantitative traits; single marker and haplotype analysis; analysis of whole genome association study data; complex trait rare variant association analysis of next generation sequence data; data quality control for genotype and next generation sequence data; haplotype reconstruction; tagSNP selection; controlling population admixture (genomic  genomic control, principal components analysis, etc); imputing genotype data from sequence and genotype data; detecting gene x gene and gene x environmental interactions; power and sample size estimation for both genotype and rare variant data; permutation (estimating empirical p-values); and false discovery rate (FDR). The organizers and instructors for the course are [https://www.bcm.edu/research/labs/center-for-statistical-genetics/ Suzanne Leal] (Baylor College of Medicine) and [http://portal.ccg.uni-koeln.de/ccg/research/stat-gen-bioinformatics/ Michael Nothnagel] (University of Cologne).

=====[httphttps://statgen.usresearch.bcm.edu/files/20152017/0906/BerlinHotelTaxExemptionFormschedule_berlin_genetic_association_course_2017.pdf Link to Berlin hotel tax exemption formClick here for course schedule]==========[https://www.mdc-berlin.de/directions Direction to the MDC Campus]==========0Direction to the classroom=====Location:

:: MDC - communication center (Building C83 on the [httphttps://wwwstatgen.campus-berlin-buchresearch.debcm.edu/enfiles/location2017/ Campus Map]):: Room Axion 2&nbsp;The building is red and stands across the street from the campus bus stop and the blue bear06/Berlin_Genetic_Association_Course_Application_2017.[[File:MDC_C.jpg|none|300x300px]]===Course Instructors===The organizers and instructors htm Click here for the course are Suzanne Leal (Baylor College of Medicine) and Michael Nothnagel (University of Cologne).application form]

[[File:2016-09_instructors.jpg|none|224x300px]] ===Course Participants===[[File:2016-09_participants1.jpg|none|400x299px]]  [[File:2016-09_participants2.jpg|none|480x203px]] ===Lecture Slides===::* [http://statgen.us/files/2016/09/auth/Berlin-lectures_2016-09.pdf Download slides here] ===Commands for Computer Exercises===::* [[2016-genetic-association-commands|View here]] ===Software Links===::* [https://faculty.washington.edu/browning/beagle/b3.html Beagle]::* EIGENSTRAT::* [http://www.genabel.org/ GenABEL]::* [http://csg.sph.umich.edu/abecasis/MACH/index.html MACH]::* [http://pngu.mgh.harvard.edu/~purcell/plink/ PLINK]::* [https://atgu.mgh.harvard.edu/plinkseq/ PSEQ]::* [http://www.r-project.org/ R]::* [http://bioinformatics.org/rv-tdt/ RV-TDT]::* [http://www.bioinformatics.org/spower/start SEQPower]::* [https://sites.google.com/site/fdudbridge/software/unphased-3-1 UNPHASED]::* [http://varianttools.sf.net/VAT Variant Association Tools]  [https://statgen.research.bcm.edu/files/2016/09/schedule_berlin_genetic_association_course_2016.pdf Click here for course schedule] [https://statgen.research.bcm.edu/files/2016/09/Berlin_Genetic_Association_Course_Application_2016.html Click here for the application form] [https://statgen.research.bcm.edu/files/20162017/0906/Berlin_genetic_association_flyer_2016schedule_berlin_genetic_association_course_2017.pdf Click here for course flyer] (please post and distribute)