ComplexNGS2025
From Statistical Genetics Courses
Complex Trait Analysis of Next Generation Sequence Data Course
September 8-12, 2025
Max Delbrück Center (MDC) for Molecular Medicine
Berlin, Germany
The eighth Berlin Complex Trait Analysis of Next Generation Sequence Data Course will be held at the MDC in Berlin from September 8 to 12, 2025. The course aims to teach the theory and application of methods for analyzing next-generation sequence (NGS) data for complex human traits. In addition to lectures, computer software will be used to analyze data, and problem-solving exercises will be performed to teach the trainees the latest method.
TOPICS: Sequence alignment, calling variants from NGS data, the VCF format, bioinformatic annotation of variants and regions, quality control of NGS data, association testing framework for quantitative and qualitative traits [fixed effects, random effects, linear mixed models (LMM) and generalized lMM (GLMM)], estimation of heritability, rare variant association methods, polygenic risk scores, pleiotropy, estimating power and sample size, and imputation of variants and their analysis
SOFTWARE: ANNOVAR, BCFtools, GCTA, Genetic Power Calculator, FASTLMM, LDSC regression, LDPHRED2, R, REGENIE
INSTRUCTORS: Suzanne Leal (Columbia University) and Michael Nothnagel (University of Cologne).
The cost of the 5-day course is €975 for researchers from an academic institution, and €1,950 for individuals from private (for-profit) companies. This fee covers tuition, A Monday evening welcome dinner, and course-related expenses (handouts, etc.) but not room, board, or additional meals. Housing is available for course participants at nearby hotels.
For additional information on the Complex Trait Analysis of NGS Data Course please contact Suzanne Leal:
Email: suzannemleal@gmail.com
APPLICATION DEADLINE: June 15, 2025
Click here for the course schedule
Click here for the application form
Click here for the course flyer (please post and distribute it)
