Zhiying Xie

Visiting PhD student

Education

• MD, Clinical medicine, Soochow University, 2016
• PhD, Neurology, Peking University, 2016 – present
• Visiting PhD student, Bioinformatics, Columbia University, 2019 – present

Research Interests

• Identification of genetic variants of inherited myopathies
• Identification of imaging biomarkers for muscular dystrophies
• Clinical and pathological research in neuromuscular disorders

Personal statement

I am a PhD student, majoring in Neurology, in the Department of neurology at Peking University First Hospital. My PhD advisor, Prof. Yun Yuan, is a neurologist specialized in neuromuscular disorders. Under his guidance, my PhD research has focused on clinical, genetic, and pathological aspects of dystrophinopathies. Currently, I am a visiting PhD student in the Center for Statistical Genetics, Department of Neurology at Columbia University. I now perform research in the field of Bioinformatics, under the supervision of Prof. Suzanne M. Leal, in identifying pathogenic variants for inherited myopathies.

My major interest is in the identification of genetic etiologies of neuromuscular disorders. I have published 12 peered reviewed articles regarding to neuromuscular disorders and most of them are related to genetic research. I am either first or co-first author on 4 of these articles.

Publications

• Xie Z, Hou Y, Yu M, Liu Y, Fan Y, Zhang W, Wang Z, Xiong H, Yuan Y. "Clinical and genetic spectrum of sarcoglycanopathies in a large cohort of Chinese patients.." Orphanet J Rare Dis.. 2019 Feb 14;14(1):43. Pubmed PMID: 30764848
• Xie Z, Xie Z, Yu M, Zheng Y, Sun C, Liu Y, Ling C, Zhu Y, Zhang W, Xiao J, Wang Z, Yuan Y. "Value of muscle magnetic resonance imaging in the differential diagnosis of muscular dystrophies related to the dystrophin-glycoprotein complex.." Orphanet J Rare Dis.. 2019 Nov 12;14(1):250. Pubmed PMID: 31747956
• Xie Z, Xiao J, Zheng Y, Wang Z, Yuan Y. "Magnetic Resonance Imaging Findings in the Muscle Tissue of Patients with Limb Girdle Muscular Dystrophy Type 2I Harboring the Founder Mutation c.545A>G in the FKRP Gene.." Biomed Res Int.. 2018 May 29;2018:3710814. Pubmed PMID: 30003095
• Yin L, Xie ZY, Xu HY, Zheng SS, Wang ZX, Xiao JX, Yuan Y. "T2 Mapping and Fat Quantification of Thigh Muscles in Children with Duchenne Muscular Dystrophy.." Curr Med Sci.. 2019 Feb;39(1):138-145. Pubmed PMID: 30868504
• Yu M, Zhu Y, Xie Z, Zheng Y, Xiao J, Zhang W, Nishino I, Yuan Y, Wang Z. "Novel TTN mutations and muscle imaging characteristics in congenital titinopathy.." Ann Clin Transl Neurol.. 2019 Jul;6(7):1311-1318. Pubmed PMID: 31353864
• Deng J, Wu W, Xie Z, Gang Q, Yu M, Liu J, Wang Q, Lv H, Zhang W, Huang Y, Wang T, Yuan Y, Hong D, Wang Z. "Novel and Recurrent Mutations in a Cohort of Chinese Patients With Young-Onset Amyotrophic Lateral Sclerosis.." Front Neurosci.. 2019 Dec 6;13:1289. Pubmed PMID: 31866807
• Yuan R, Yi J, Xie Z, Zheng Y, Han M, Hou Y, Wang Z, Yuan Y. "Genotype-phenotype correlation in Becker muscular dystrophy in Chinese patients.." J Hum Genet.. 2018 Oct;63(10):1041-1048. Pubmed PMID: 29976999
• Liu Y, Zheng Y, Gang Q, Xie Z, Jin Y, Zhang X, Deng X, Hao H, Gao F, Zhang Z, Xiong H, Zhang W, Wang Z, Yuan Y. "Perimysial microarteriopathy in dermatomyositis with anti-nuclear matrix protein-2 antibodies.." Eur J Neurol.. 2020 Mar;27(3):514-521. Pubmed PMID: 31571350
• Deng J, Lu Y, Xie Z, Liu J, Yuan Y, Wang Z. "RNA-seq profiling, and impaired autophagic process in skeletal muscle of MELAS.." Biochem Biophys Res Commun.. 2020 Feb 26;523(1):91-97. Pubmed PMID: 31836143
• Hou Y, Xie Z, Zhao X, Yuan Y, Dou P, Wang Z. "Appendicular skeletal muscle mass: A more sensitive biomarker of disease severity than BMI in adults with mitochondrial diseases.." PLoS One.. 2019 Jul 25;14(7):e0219628. Pubmed PMID: 31344055
• Li J, Meng L, Wu R, Xie Z, Gang Q, Zhang W, Wang Z, Yuan Y. "Sural nerve pathology in TFG-associated motor neuron disease with sensory neuropathy.." Neuropathology. 2019 Jun;39(3):194-199. Pubmed PMID: 30957313
• An J, Xie Z, Jia F, Wang Z, Yuan Y, Zhang J, Fang J. "Quantitative coordination evaluation for screening children with Duchenne muscular dystrophy.." Chaos. 30, 023116 (2020)

Contact Information

Leal Lab

• Address: 622 W. 168th St, 19th floor, New York, NY 10032
• Email: xiezhiyingxzy [at] 163.com