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ComplexNGS2025

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/* Complex Trait Analysis of Next Generation Sequence Data Course */
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=Complex Trait Analysis of Next Generation Sequence Data Course=
<div style="text-align: left;">September 8-12, 2025<br />
Max Delbrück Center (MDC) for Molecular Medicine<br />
Berlin, Germany</div>
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The eighth Complex Trait Analysis of Next Generation Sequence Data Course will be held at the [https://www.mdc-berlin.de/ MDC] in Berlin from September 8 to 12, 2025. The course aims to teach the theory and application of methods for analyzing next-generation sequence (NGS) data for complex human traits. In addition to lectures, computer software will be used to analyze data, and problem-solving exercises will be performed to teach the trainees the latest method.
The eighth Berlin Complex Trait Analysis of Next Generation Sequence Data Course will be held at the [https'''TOPICS://www.mdc-berlin.de/ MDC] in Berlin ''' Sequence alignment, calling variants from September 8 to 12NGS data, 2025. The course aims to teach the theory VCF format, bioinformatic annotation of variants and application regions, quality control of methods for analyzing next-generation sequence (NGS) data , association testing framework for complex human quantitative and qualitative traits. In addition to lectures[fixed effects, computer software will be used to analyze datarandom effects, linear mixed models (LMM) and problem-solving exercises will be performed to teach the trainees the latest method.generalized lMM (GLMM)], estimation of heritability, rare variant association methods, polygenic risk scores, pleiotropy, estimating power and sample size, and imputation of variants and their analysis
TOPICS'''SOFTWARE''': Sequence alignmentANNOVAR, calling variants from NGS dataBCFtools, the VCF formatGCTA, bioinformatic annotation of variants and regionsGenetic Power Calculator, quality control of NGS dataFASTLMM, association testing framework for quantitative and qualitative traits [fixed effectsLDSC regression, random effectsLDPHRED2, linear mixed models (LMM) and generalized lMM (GLMM)]R, estimation of heritability, rare variant association methods, polygenic risk scores, pleiotropy, estimating power and sample size, and imputation of variants and their analysisREGENIE
SOFTWARE: ANNOVAR, BCFtools, GCTA, Genetic Power Calculator, FASTLMM, LDSC regression, LDPHRED2, R, REGENIE '''INSTRUCTORS''': Suzanne Leal (Columbia University) and Michael Nothnagel (University of Cologne).
The cost of the 5-day course is &euro;975 for researchers from an academic institution, and &euro;1,950 for individuals from private (for-profit) companies. This fee covers tuition, A Monday evening welcome dinner, and course-related expenses (handouts, etc.) but not room, board, or additional meals. Housing is available for course participants at nearby hotels.
 
For additional information on the Complex Trait Analysis of NGS Data Course please contact [mailto:suzannemleal@gmail.com?subject=Complex%20Trait%20Analysis%20Course%20Berlin%202023 Suzanne Leal]:
Email: [mailto:suzannemleal@gmail.com?subject=Complex%20Trait%20Analysis%20Course%20Berlin%202023 suzannemleal@gmail.com]
APPLICATION DEADLINE: June 15, 2025   [https://github.com/statgenetics/statgen-courses/blob/master/schedules/schedule_berlin_complex_ngs_2025.pdf Click here for the course schedule] [https://github.com/statgenetics/statgen-courses/raw/refs/heads/master/applications/Berlin_NGS_Complex_Trait_Application_2025.docx Click here for the application form]'''
<div style="text-align: left;">[https://raw.githubusercontent.com/statgenetics/statgen-courses/refs/heads/master/schedules/schedule_berlin_complex_ngs_2025.pdf Click here for the course schedule]</div><div style="text-align: left;">[https://github.com/statgenetics/statgen-courses/blobraw/refs/heads/master/applications/Berlin_NGS_Complex_Trait_Application_2025.docx Click here for the application form]</div><div style="text-align: left;">[https://raw.githubusercontent.com/statgenetics/statgen-courses/refs/heads/master/flyer/Berlin_NGS_complex_traits_course_flyer_2025.pdf Click here for the course flyer (please post and distribute it)]</div>
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