# This file includes a series of comments. Each comment is marked # by a # character as the first character in the line. # # This is a comment! # Meta-analysis weighted by standard error does not work well # when different studies used very different transformations. # In this case, some attempt was made to use similar trait # transformation and you can request a standard error based # analysis by uncommenting the following line: # SCHEME STDERR # Usually, it is a good to apply genomic control to each # input file. However, in this example, all the markers being # examined reside in strongly associated loci and it probably # is not a good idea. To find out what happens if you turn # on genomic control, uncomment the following line. # GENOMICCONTROL ON # To help identify allele flips, it can be useful to track # allele frequencies in the meta-analysis. To enable this # capability, uncomment the following two lines. # AVERAGEFREQ ON # MINMAXFREQ ON # To restric meta-analysis to two previously reported SNPs # and summarize study specific results, uncomment the two # lines that follow. # ADDFILTER SNP IN (rs10830963,rs563694) # VERBOSE ON # Describe and process the DGI input files MARKER SNP WEIGHT N ALLELE EFFECT_ALLELE NON_EFFECT_ALLELE FREQ EFFECT_ALLELE_FREQ EFFECT BETA STDERR SE PVAL P_VAL PROCESS DGI_three_regions.txt # Describe and process the FUSION input files MARKER SNP ALLELE EFFECT_ALLELE NON_EFFECT_ALLELE FREQ FREQ_EFFECT WEIGHT N EFFECT BETA STDERR SE PVAL PVALUE PROCESS MAGIC_FUSION_Results.txt.gz # Describe and process the SardiNIA input files MARKER SNP DEFAULT 4106 ALLELE AL1 AL2 FREQ FREQ1 EFFECT EFFECT STDERR SE PVAL PVALUE PROCESS magic_SARDINIA.tbl # Execute meta-analysis ANALYZE